Proteolytic cascade in the amyloidogenesis of Alzheimer's disease
| Autor: | Brian M. Austen, Richard B. Parsons, Christina Sidera |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Amyloid beta-Peptides Glycosylation Peptide Disease Cellular targeting Hydrogen-Ion Concentration Biochemistry Cell Line Cholesterol chemistry Gene Expression Regulation Alzheimer Disease Endopeptidases Aspartic Acid Endopeptidases Humans Androstenes Amyloid Precursor Protein Secretases Protein Processing Post-Translational Proteolytic cascade Intracellular Signal Transduction |
| Zdroj: | King's College London |
| ISSN: | 0300-5127 |
| Popis: | β-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. β-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which are dispersed by statins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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