Morphological brain changes associated with Schneider's first-rank symptoms in schizophrenia: an MRI study
| Autor: | Shi-Yu Zhou, Hikaru Seto, T. Ono, H. Hagino, Lisha Niu, Yukako Kawasaki, Tsutomu Takahashi, Masayoshi Kurachi, Michio Suzuki, Mie Matsui |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cingulate cortex medicine.medical_specialty Statistics as Topic Prefrontal Cortex Audiology Gyrus Cinguli Hippocampus behavioral disciplines and activities Temporal lobe Imaging Three-Dimensional Image Processing Computer-Assisted medicine Humans Dominance Cerebral Prefrontal cortex Applied Psychology Psychiatric Status Rating Scales Brain Mapping Precentral gyrus Limbic lobe Amygdala Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Psychiatry and Mental health Emotional lateralization medicine.anatomical_structure nervous system Frontal lobe Schizophrenia Parahippocampal Gyrus Female Schizophrenic Psychology Nerve Net Psychology Neuroscience psychological phenomena and processes Parahippocampal gyrus |
| Zdroj: | Psychological Medicine. 35:549-560 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291704003885 |
| Popis: | Background. Schneider's first-rank symptoms involve an alienated feature of the sense of one's own mental or physical activity. To clarify the brain morphological basis for the production of these symptoms, volumes of the frontal and medial temporal regions and their clinical correlates were examined in patients with schizophrenia.Method. Twenty-two patients with schizophrenia and 44 age- and gender-matched healthy control subjects were included. All patients were in their psychotic episodes with definite Schneiderian symptoms, rated by using the Scale for Assessment of Positive Symptoms. Volumetric measurements of high-resolution magnetic resonance imaging were performed in the prefrontal area, cingulate gyrus, and precentral gyrus, and the medial temporal structures such as the amygdala, hippocampus, and parahippocampal gyrus.Results. Patients had significantly decreased volumes in the cingulate gray matter and the amygdala compared to controls. In the patient group, Schneiderian symptom severity showed significant inverse correlations with volumes of the right posterior cingulate gray matter and of the left anterior parahippocampal gyrus.Conclusions. Schneiderian symptoms may be associated with morphological abnormalities in the limbic-paralimbic regions such as the cingulate gyrus and parahippocampal gyrus, which possibly serve the self-monitoring function and the coherent storage and reactivation of information. |
| Databáze: | OpenAIRE |
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