Differentiating highly asymmetric keratoconus eyes using a combined Scheimpflug/Placido device
| Autor: | Eliya Levinger, Oren Golan, Irit S Barequet, David Varssano, Samuel Levinger, J. Bradley Randleman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Keratoconus genetic structures Corneal Pachymetry Tel aviv medicine.medical_treatment Scheimpflug principle Cornea 03 medical and health sciences 0302 clinical medicine Posterior wall Ophthalmology Refractive surgery Medicine Humans Retrospective Studies Horizontal axis Receiver operating characteristic business.industry Corneal Topography medicine.disease eye diseases Sensory Systems medicine.anatomical_structure ROC Curve 030221 ophthalmology & optometry Surgery sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Journal of cataract and refractive surgery. 46(12) |
| ISSN: | 1873-4502 |
| Popis: | PURPOSE To determine the ability to differentiate between normal eyes and clinically unaffected eyes of patients with highly asymmetric keratoconus (AKC) using a Scheimpflug/Placido device. SETTING Tel Aviv Sourasky Medical Center and Enaim Medical Center, Israel. DESIGN Retrospective case-control. METHODS Imaging from a combined Scheimpflug/Placido device (Sirius, C.S.O.) was obtained from 26 clinically unaffected eyes of patients with frank keratoconus in the fellow eye, and 166 eyes from 166 patients with bilaterally normal corneal examinations that underwent uneventful corneal refractive surgery with at least 1 year of follow-up. Receiver operating characteristic curves were produced to calculate the area under the curve, sensitivity, and specificity of 60 metrics, and finally a logistic regression modeling was used to determine optimal variables to differentiate populations. RESULTS The most predictive individual metric able to differentiate between 26 eyes in the case group to 166 eye in the control group was the posterior wall inferior-superior (I-S) ratio, with an receiver operating characteristics (ROC) of 0.862. A combination model of 4 metrics (posterior wall I-S ratio in the central 3 mm, thinnest pachymetry coordinate on the x horizontal axis, posterior asymmetry and asphericity index, corneal volume) yielded an ROC of 0.936, with a sensitivity/specificity pair of 92.3%/87%. Variables related to elevation were not found significant. CONCLUSIONS Using a combination of metrics from a combined Scheimpflug/Placido device, a practical model for discrimination between clinically normal eyes of patients with highly AKC and normal eyes was constructed. Variables related to pachymetry and posterior cornea asymmetry were the most impactful. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|