Azithromycin and terfenadine: lack of drug interaction
| Autor: | Stuart J. Harris, Mark Eller, Philip M. Colangelo, Donald M. Hilligoss, Richard R. Okerholm |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pharmacology Azithromycin Placebo QT interval Placebos Electrocardiography Pharmacokinetics Double-Blind Method Oral administration Medicine Humans Pharmacology (medical) Terfenadine Drug Interactions business.industry Drug interaction Anti-Bacterial Agents Pharmacodynamics Anesthesia Histamine H1 Antagonists business medicine.drug |
| Zdroj: | Clinical pharmacology and therapeutics. 58(3) |
| ISSN: | 0009-9236 |
| Popis: | A double-blind placebo-controlled study was conducted in healthy men to determine the effect of coadministration of azithromycin on the pharmacodynamics and pharmacokinetics of terfenadine. Administration of 500 mg azithromycin for 1 day and 250 mg on 4 subsequent days did not affect the pharmacokinetics of the pharmacologically active terfenadine carboxylate metabolite when 60 mg terfenadine was given twice daily for 12 days, starting 7 days before azithromycin administration. Terfenadine alone resulted in a 0.010 msec increase in the rate-corrected QT interval (QTc), but the incremental effects of azithromycin and placebo on QTc in volunteers receiving terfenadine were not statistically different. It is concluded that the potentially life-threatening disorders that have been attributed to a pharmacokinetic interaction between macrolide antibiotics and terfenadine are unlikely to take place in patients treated simultaneously with azithromycin and terfenadine. |
| Databáze: | OpenAIRE |
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