Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 CT, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms
| Autor: | Mihaela Tevet, Radu A. Popp, Claudia Bănescu, Adrian P. Trifa, Ștefan Cristian Vesa, Cristina Skrypnyk, Meilin Murat, Anca Bojan, Ioan Victor Pop, Delia Dima, Valeriu Moldovan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male GPX1 medicine.medical_specialty Genotype Fusion Proteins bcr-abl Biology Genes abl Polymorphism Single Nucleotide 03 medical and health sciences GSTP1 0302 clinical medicine Myeloproliferative Disorders Polycythemia vera Glutathione Peroxidase GPX1 hemic and lymphatic diseases Molecular genetics medicine Humans Myelofibrosis Aged Glutathione Transferase Aged 80 and over Glutathione Peroxidase Essential thrombocythemia Superoxide Dismutase Hematology Middle Aged medicine.disease Catalase Oxidative Stress 030104 developmental biology Glutathione S-Transferase pi 030220 oncology & carcinogenesis Immunology Female |
| Zdroj: | Hematology (Amsterdam, Netherlands). 21(9) |
| ISSN: | 1607-8454 |
| Popis: | Objectives: To analyze the relationship between six polymorphisms in genes related to oxidative stress, namely CAT-262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu, GSTM1 and GSTT1 null genotypes, and GSTP1 Ile105Val, and the occurrence of BCR-ABL negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis).Methods: We genotyped for these polymorphisms 328 patients with a known mutation status for JAK2 V617F, MPL and CALR, and 363 controls, using molecular genetics assays.Results: The CAT-262 C>T and GPX1 Pro198Leu polymorphisms were seen significantly less frequently, while the GSTP1 IleVal105 polymorphism was seen significantly more frequently in patients with BCR-ABL negative myeloproliferative neoplasms, regardless of the molecular sub-type (e.g. JAK2 V617F or CALR mutated).Discussion and conclusion: Our study provides evidence that variation in genes related to oxidative stress might modulate the risk of developing BCR-ABL negative myeloproliferative neoplasms. |
| Databáze: | OpenAIRE |
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