Neuronal antibody prevalence in children with seizures under 3 years: A prospective national cohort
| Autor: | Mary Callaghan, Selina Thomsen, Calum A. Morrison, Alan Webb, Andreas Brunklaus, T Moloney, Jane MacDonnell, Ishaq Abu-Arafeh, Lesley Nairn, Bethan Lang, S. MacLeod, Ailsa McLellan, Alice Jollands, Jayakara Shetty, Elma Stephen, Jamie Cruden, Elizabeth Pilley, Joseph D. Symonds, Margaret Wilson, Jean McKnight, Martin Kirkpatrick, Christine Findlay, Liam Dorris, Kirsten Forbes, Sameer M. Zuberi, Philip Brink, Angela Vincent, Mary O'Regan, Jamie Andrew, Rosemary Grattan |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Population Hashimoto Disease Cohort Studies 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures Internal medicine medicine Humans Prospective Studies Prospective cohort study education Autoantibodies Autoimmune encephalitis education.field_of_study biology business.industry Autoantibody Infant medicine.disease United Kingdom 030104 developmental biology Child Preschool Cohort biology.protein Encephalitis Female Neurology (clinical) Antibody business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Symonds, J D, Moloney, T C, Lang, B, McLellan, A, O'Regan, M, MacLeod, S, Jollands, A, Vincent, A, Kirkpatrick, M, Brunklaus, A, Shetty, J, Dorris, L, Forbes, K, Abu-Arafeh, I, Andrew, J, Brink, P, Callaghan, M, Cruden, J, Findlay, C, Grattan, R, MacDonnell, J, McKnight, J, Morrison, C A, Nairn, L, Pilley, E, Stephen, E, Thomsen, S, Webb, A, Wilson, M & Zuberi, S M 2020, ' Neuronal antibody prevalence in children with seizures under 3 years : A prospective national cohort ', Neurology, vol. 95, no. 11, 11 . https://doi.org/10.1212/WNL.0000000000010318 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | ObjectiveTo report the prevalence of anti-neuronal antibodies in a prospective whole-nation cohort of children presenting with seizures before their third birthday.MethodsThis was a prospective population-based national cohort study involving all children presenting with new-onset epilepsy or complex febrile seizures before their third birthday over a 3-year period. Patients with previously identified structural, metabolic, or infectious cause for seizures were excluded. Serum samples were obtained at first presentation and tested for 7 neuronal antibodies using live cell-based assays. Clinical data were collected with structured proformas at recruitment and 24 months after presentation. In addition, patients with seizures and clinically suspected autoimmune encephalitis were independently identified by a review of the case records of all children ResultsTwo hundred ninety-eight patients were identified and recruited and underwent autoantibody testing. Antibody positivity was identified in 18 of 298 (6.0%). The antibodies identified were GABA receptor B (n = 8, 2.7%), contactin-associated protein 2 (n = 4, 1.3%), glycine receptor (n = 3, 1.0%), leucine-rich glioma inactivated 1 (n = 2, 0.7%), NMDA receptor (n = 1, 0.3%), and GABA receptor A (n = 1, 0.3%). None of these patients had a clinical picture of autoimmune encephalitis. Seizure classification and clinical phenotype did not correlate with antibody positivity.ConclusionsAutoimmune encephalitis is very rare in early childhood. However serum neuronal antibodies are identified in 6.4% of children presenting with seizures at |
| Databáze: | OpenAIRE |
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