Attenuation of the antinociceptive action of the selective κ-opioid receptor agonist, U-50,488H by ICS-205-930
| Autor: | A. E. Takemori, Begonia Y. Ho |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Indoles Pyrrolidines Ratón medicine.drug_class Tropisetron Analgesic Pharmacology Mice Reaction Time medicine Animals Receptor Injections Spinal ED50 Injections Intraventricular Analgesics business.industry Receptors Opioid kappa 3 4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide (trans)-Isomer Drug interaction Receptor antagonist Nociception Receptors Opioid Serotonin business |
| Zdroj: | European Journal of Pharmacology. 178:371-373 |
| ISSN: | 0014-2999 |
| Popis: | The antinociceptive action of s.c. administered U-50,488H was antagonized by s.c. administered ICS-205-930, a selective 5-HT3 receptor antagonist. To characterize the site of interaction, U-50,488H and ICS-205-930 were administered either intracerebroventricularly (i.c.v.) or intrathecally (i.t.). When U-50,488H was administered i.c.v., its antinociception action was antagonized by ICS-205-930 given either i.c.v. or i.t., increasing the ED50 values of U-50,488H by approximately twofold from 48 to 98 and 90 nmol/mouse, respectively. However, when U-50,488H was administered i.t., its antinociception action was not antagonized by ICS-205-930 given either i.c.v. or i.t. These findings suggest that i.c.v., but not i.t. administered U-50,488H may release serotonin both supraspinally and spinally to interact with 5-HT3 receptors to produce antinociception. |
| Databáze: | OpenAIRE |
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