Aggressive Squamous Cell Carcinomas in Persons Infected With the Human Immunodeficiency Virus
| Autor: | Kirsten Vin-Christian, Patricia Nguyen, Timothy G. Berger, Michael E. Ming |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Skin Neoplasms medicine.medical_treatment HIV Infections Dermatology Risk Assessment Severity of Illness Index Sampling Studies Metastasis Immunocompromised Host Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine medicine Humans Neoplasm Metastasis Risk factor Sida Neoplasm Staging Retrospective Studies biology business.industry Incidence Immunosuppression Neck dissection General Medicine Prognosis medicine.disease biology.organism_classification Surgery Survival Rate Radiation therapy stomatognathic diseases Epidermoid carcinoma Carcinoma Squamous Cell Female business |
| Zdroj: | Archives of Dermatology. 138:758 |
| ISSN: | 0003-987X |
| DOI: | 10.1001/archderm.138.6.758 |
| Popis: | Objectives To illustrate the potential for aggressive growth of cutaneous squamous cell carcinomas (SCCs) in patients infected with the human immunodeficiency virus (HIV) and to determine the factors associated with increased morbidity and mortality from aggressive SCCs in HIV-infected patients. Design Retrospective nonrandomized case series. Setting University-based dermatologic referral center. Patients A consecutive sample of 10 patients infected with HIV who had "aggressive" SCC based on the following criteria: diameter larger than 1.5 cm, rapid growth rate, local recurrence, and/or evidence of metastasis. Main Outcome Measures Morbidity and mortality. Results Five patients died of metastatic SCC within 7 years of their initial diagnosis despite treatment. Human immunodeficiency virus stage and the degree of immunosuppression were not associated with increased morbidity and mortality. Patients initially undergoing combination surgery and radiation therapy or radical neck dissection had the best outcomes. Conclusions Patients infected with HIV can develop rapidly growing cutaneous SCCs at a young age, with a high risk of local recurrence and metastasis. High-risk SCCs should be managed aggressively and not palliatively in patients infected with HIV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|