VKORC1-1639A allele influences warfarin maintenance dosage among Blacks receiving warfarin anticoagulation: a retrospective cohort study
Autor: | Cathy Lally, Christine De Staercke, Fatima D. Mili, W. Craig Hooper, Harland Austin, Christopher J. Bean, Paula Weinstein Wadell, Tenecia Allen, Nanette K. Wenger |
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Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_specialty Georgia Time Factors Genotype Single-nucleotide polymorphism 030204 cardiovascular system & hematology Polymerase Chain Reaction Polymorphism Single Nucleotide 030226 pharmacology & pharmacy Article 03 medical and health sciences 0302 clinical medicine Therapeutic index Vitamin K Epoxide Reductases Internal medicine medicine Humans CYP2C9 Alleles Retrospective Studies Dose-Response Relationship Drug Maintenance dose business.industry Incidence Warfarin Anticoagulants Thrombosis Retrospective cohort study Middle Aged Black or African American Molecular Medicine Female VKORC1 Cardiology and Cardiovascular Medicine business Pharmacogenetics Follow-Up Studies medicine.drug |
Zdroj: | Future Cardiology. 14:15-26 |
ISSN: | 1744-8298 1479-6678 |
Popis: | Aim: The study objectives were to investigate the association between selected CYP2C9 and VKORC1 single nucleotide polymorphisms with serious bleeding or thrombotic risk, and to estimate mean daily maintenance dose of warfarin and international normalized ratio measurements among Blacks receiving warfarin anticoagulation. Methods: We conducted a retrospective cohort study among 230 Black adults receiving warfarin for a minimum of three consecutive months with a confirmed date of first dosage. Results: A lower mean daily maintenance dosage of warfarin was required to maintain an international normalized ratio measurement within the therapeutic range among Blacks with the VKORC1-1639G>A variant alleles ([G/A vs G/G, p = 0.02], [A/A vs G/A, p = 0.008] and [A/A vs G/G, p = 0.001]). Conclusion: Data indicated that VKORC1-1639A variant allele influenced warfarin daily maintenance dosage among our small, likely admixed Black patient population. |
Databáze: | OpenAIRE |
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