Growth hormone, dehydroepiandrosterone and adiponectin levels in non-alcoholic steatohepatitis: an endocrine signature for advanced fibrosis in obese patients
| Autor: | Kymberly D. Watt, Schuyler O. Sanderson, James Swain, Edith Koehler, Anuradha Krishnan, Michael Charlton |
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| Rok vydání: | 2011 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Severity of Illness Index Insulin resistance Non-alcoholic Fatty Liver Disease Fibrosis Internal medicine medicine Humans Obesity Hepatology Adiponectin business.industry Leptin Quantitative insulin sensitivity check index Fatty liver nutritional and metabolic diseases Dehydroepiandrosterone Middle Aged medicine.disease digestive system diseases Fatty Liver Endocrinology Growth Hormone Female Resistin Steatohepatitis business Biomarkers |
| Zdroj: | Liver International. 32:279-286 |
| ISSN: | 1478-3223 |
| Popis: | Background and Aims Liver-related clinical consequences of non-alcoholic fatty liver disease (NAFLD) are seen only in the minority of patients with advanced fibrosis. The aim of our study was to generate insight into a potential endocrine basis of steatohepatitis with advanced fibrosis in NAFLD. Methods Biopsy and blood samples were prospectively collected from patients with medically complicated obesity. Patients were categorized, according to liver histology, into: (i) normal, (ii) simple steatosis (SS), (iii) non-alcoholic steatohepatitis (NASH) with fibrosis stage (FS) 0–1 and (iv) NASH with FS ≥ 2. A broad panel of potential biomarkers included DHEA-S, growth hormone (GH), homeostasis model assessment-insulin resistance (HOMA-IR), leptin, resistin, adiponectin and cytokeratin 18 (CK-18) fragments. Results We studied 160 patients (mean BMI 46.8 ± 8.2 kg/m2). Liver biopsies demonstrated normal histology in 10%, SS in 45%, NASH with FS 0–1 in 37.5% and NASH with FS ≥ 2 in 7.5%. C-reactive protein, IL-6, GH, CK-18, adiponectin, HOMA-IR and quantitative insulin sensitivity check index (QUICKI) were significantly associated with NASH in univariate analysis, but overall predictivity of these parameters was low (AUC ROC = 0.62–0.68). In contrast, all patients with NASH with FS ≥ 2 had insulin resistance, as measured by QUICKI, and GH levels |
| Databáze: | OpenAIRE |
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