Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy
| Autor: | Yael Rosenberg-Hasson, Holden T. Maecker, Raymund Ramirez, Jeanne Talucod, Remy Estran, Tyson H. Holmes, Jose G. Montoya, Cynthia Press, Christelle Pomares |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent medicine.medical_treatment Immunology Biochemistry Asymptomatic Serology 03 medical and health sciences Lymphadenitis Pregnancy Humans Immunology and Allergy Medicine In patient Molecular Biology Aged Retrospective Studies Aged 80 and over business.industry Retrospective cohort study Hematology Middle Aged medicine.disease Toxoplasmosis Titer 030104 developmental biology Cytokine Pregnancy Complications Parasitic Cytokines Female medicine.symptom business Toxoplasma |
| Zdroj: | Cytokine. 90:14-20 |
| ISSN: | 1043-4666 |
| Popis: | Majority of Toxoplasma gondii infections are benign and asymptomatic; however, some patients experience toxoplasmic lymphadenitis (TL). Factors associated as to whether infection will be symptomatic or not are unknown.Dye test titers of patients with acute toxoplasmosis (pregnant and not pregnant) with TL (TL+) were compared with those in patients with asymptomatic acute infection (TL-). Additionally, mean levels of 62 serum cytokines were compared between TL+ and TL- pregnant women and between TL+ pregnant and non-pregnant women.During acute infection, mean dye test titer was higher in TL+ than in TL- patients (p=0.021). In addition, out of 62 cytokines, CXCL9andCXCL10 levels were higher (p0.05) and resistin mean levels were lower (p0.05) in pregnant women with TL+ compared to TL-. Among patients with TL+, levels of VCAM1andCCL2 were lower (p0.05) in pregnant women than in non-pregnant women.Here we report differences in dye test titers in patients with acute infection. Cytokine responses vary according to the presence of TL+ and to the pregnancy status. Factors underlying these differences are presently unknown and require further studies to define individual and combined roles of cytokines in TL+. |
| Databáze: | OpenAIRE |
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