Post-Chernobyl incidence of papillary thyroid cancer among Belgian children less than 15 years of age in April 1986: a 30-year surgical experience
| Autor: | Julian Donckier, Claude Bertrand, Caroline Fervaille, Alain Rosière, Julien Lemaire, Luc Michel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Neoplasms Radiation-Induced Time Factors endocrine system diseases medicine.medical_treatment Chernobyl Nuclear Accident Risk Assessment Disease-Free Survival Papillary thyroid cancer Thyroid carcinoma Cohort Studies 03 medical and health sciences 0302 clinical medicine Belgium medicine Carcinoma Humans Thyroid Neoplasms Child Retrospective Studies business.industry Incidence (epidemiology) Thyroidectomy Retrospective cohort study General Medicine medicine.disease Prognosis Survival Analysis Carcinoma Papillary 030104 developmental biology Treatment Outcome Thyroid Cancer Papillary 030220 oncology & carcinogenesis Child Preschool Surgery Female business Nuclear medicine Cohort study |
| Zdroj: | Acta chirurgica Belgica. 116(2) |
| ISSN: | 0001-5458 |
| Popis: | We raised the question of a possible relationship in Belgium between the occurrence of papillary thyroid carcinoma (PTC) and age of children (15 years) at the time of the Chernobyl nuclear plant accident in April 1986.Referral university centre for endocrine surgery.Thirty-year prospective study of the experience of a surgical team with PTC since the Chernobyl accident, taken out of 2349 patients operated on for any thyroid lesions from April 1986 to April 2015, comparing the incidence of PTC by age groups.Comparison of PTC incidence in patients15 years (group A) and children15 years (group B) in April 1986.Out of a total of 2349 patients having undergone thyroid surgery for all types of lesions during 30 year after Chernobyl and born before April 1986, 2164 were15 years of age at the time of the nuclear accident (group A) and 175 developed PTC (8.1%) compared to 36 PTC (19.5%) that occurred in 185 children15 years of age (group B) in April 1986 (p 0.001).Radiation exposure affected residents of countries (including Belgium) well beyond Ukraine and Belarus. This was demonstrated by a 1990 meteorological report. Over 30 years, there has been a persistent higher incidence of PTC among Belgian children below the age of 15 years at the time of the Chernobyl accident. This relationship with age has even been strengthened by the implementation of more sophisticated immunohistochemical biomarkers diagnostic technology since April 2011. |
| Databáze: | OpenAIRE |
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