Assessment of lectin binding for prognosis in endometrial carcinoma
| Autor: | Y Ookuma, Hajime Sugimori, Tsuyoshi Iwasaka, Hachisuga T |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Peanut agglutinin
Pathology medicine.medical_specialty Adenocarcinoma Endometrium Pathology and Forensic Medicine Immunoenzyme Techniques Peanut Agglutinin Agglutinin Lectins medicine Carcinoma Humans Neoplasm Staging biology Lectin Prognosis medicine.disease Survival Analysis Endometrial Neoplasms Staining medicine.anatomical_structure cardiovascular system biology.protein Immunohistochemistry Female Plant Lectins Neuraminidase |
| Zdroj: | Pathology. 26:225-229 |
| ISSN: | 0031-3025 |
| DOI: | 10.1080/00313029400169551 |
| Popis: | Summary The binding of Ulex europeus agglutinin-I (UEA-I) and Peanut agglutinin (PNA) was studied in 56 endometrial carcinomas. The positive rates of UEA-I and PNA were 66%. Following neuraminidase treatment, the PNA positive rate increased from 66% to 98% and most tumors stained abu0dantly. UEA-I staining was unaffected. Using a combined grading system based on architectural and nuclear abnormalities, the PNA positive rates of grade 1, grade 2 and grade 3 tumors were 78%, 70% and 36%, respectively. There was no correlation between UEA-I binding and the grading systems. UEA-I binding correlated significantly with the presence of myometrial invasion and vessel permeation. Metastatic endometrial carcinomas showed a high affinity of tumor cells for UEA-I. Tissues that stained with UEA-I were those from patients with the worst prognosis. PNA and UEA-I reactivities relate to the biologic activity of endometrial carcinomas. UEA-I can serve as a prognostic marker for patients with endometrial carcinoma. |
| Databáze: | OpenAIRE |
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