The evaluation of HLA-DRB1 antigens as susceptibility markers for unilocular cystic echinococcosis in Egyptian patients
Autor: | Laila M El-Hoseiny, Reda M. R. Ramzy, Nihad M Oteifa, Magda E. Azab, Mona A. Ahmed, Sawsan A Bishara |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male medicine.medical_specialty Pathology Echinococcosis Pulmonary Adolescent Genotype Genes MHC Class II Helminthiasis Human leukocyte antigen Disease HLA-DR3 Antigen Medical microbiology Antigen Echinococcosis Risk Factors parasitic diseases medicine Humans Genetic Predisposition to Disease Genetic Testing Typing Child HLA-DRB1 Alleles Aged HLA-DR Serological Subtypes General Veterinary business.industry Cystic echinococcosis HLA-DR Antigens General Medicine Middle Aged medicine.disease Infectious Diseases Child Preschool Insect Science Egypt Female Parasitology Disease Susceptibility business HLA-DRB1 Chains |
Zdroj: | Parasitology Research. 92:473-477 |
ISSN: | 1432-1955 0932-0113 |
Popis: | This is the first study dealing with the correlation between HLA antigens and cystic echinococcosis (CE) in Egyptian patients. The potential immunogenetic predisposition for susceptibility and resistance to unilocular echinococcosis was investigated by HLA-DRB1 typing; first by HLA-DRB1 amplification using PCR then using the allele-specific probing technique based on the reverse hybridization principle. The study was carried out on 35 patients with confirmed CE, and 100 apparently healthy individuals. A statistically significant positive association was found between HLA-DR3 and HLA-DR11 and the occurrence of CE. HLA-DR3 antigen was positively associated with the occurrence of isolated pulmonary cysts, multiple cysts, cysts >5 cm in size, non-cured disease and with a common radiological picture of hydatid cyst. A significant positive association of HLA-DR11 with the occurrence of cysts |
Databáze: | OpenAIRE |
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