Colorectal Cancer: Chemopreventive Role of Curcumin and Resveratrol
| Autor: | Sabeena Misra, Adhip P.N. Majumdar, Bhaumik B. Patel, Vaishali Patel |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty Curcumin Adenoma Colorectal cancer medicine.medical_treatment Medicine (miscellaneous) Resveratrol Gastroenterology Article chemistry.chemical_compound Internal medicine Stilbenes Carcinoma medicine Animals Anticarcinogenic Agents Humans Adverse effect Chemotherapy Clinical Trials as Topic Nutrition and Dietetics business.industry Cancer medicine.disease digestive system diseases Oncology chemistry Cancer research business Colorectal Neoplasms |
| Popis: | Colorectal cancer (CRC) is a second leading cause of cancer deaths in the Western world. Currently there is no effective treatment except resection at a very early stage with or with-out chemotherapy. Of various epithelial cancers, CRC in particular has a potential for prevention, since most cancers follow the adenoma-carcinoma sequence, and the interval between detection of an adenoma and its progression to carcinoma is usually about a decade. However no effective chemopreventive agent except COX-2 inhibitors, limited in their scope due to cardiovascular side effects, have shown promise in reducing adenoma recurrence. To this end, natural agents that can target important carcinogenic pathways without demonstrating discernible adverse effects would serve as ideal chemoprevention agents. In this review, we discuss merits of two such naturally occurring dietary agents—curcumin and resveratrol—for chemoprevention of CRC. |
| Databáze: | OpenAIRE |
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