Comparing the performance of CA 15–3 CSF to cytology in a cohort of patients with breast cancer leptomeningeal metastasis
| Autor: | Stacy M. Kenyon, Alicia Algeciras-Schimnich, Tifani L. Flieth |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Disease status Concordance Clinical Biochemistry CA 15-3 Breast Neoplasms Gastroenterology 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Cytology Meningeal Neoplasms medicine Humans Neoplasm Metastasis Retrospective Studies Tumor marker Histocytochemistry business.industry Mucin-1 General Medicine medicine.disease Neoplasm Proteins 030104 developmental biology 030220 oncology & carcinogenesis Cohort Female business Leptomeningeal metastasis |
| Zdroj: | Clinical Biochemistry. 58:122-124 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2018.06.004 |
| Popis: | Background and objective Leptomeningeal metastasis (LM) can occur as a late manifestation of breast cancer and has traditionally been diagnosed by CSF cytology; however, cytology suffers from low sensitivity and it is believed that many cases of LM go undiagnosed. Some studies have suggested the use of CA 15–3 in CSF (CA 15–3 CSF) to aid in the detection of LM. The purpose of this study was to compare the performance of CA 15–3 CSF to cytology for the detection and treatment monitoring of breast cancer LM. Methods CA 15–3 CSF requests between 2014 and 2016 were retrospectively reviewed. Fifty-two measurements from nine patients were from our health system and had corresponding CSF cytology measurements. Concordance between CA 15–3 CSF and CSF cytology was calculated. For patients with quantifiable CA 15–3 CSF, sequential determinations of CA 15–3 and cytology were compared over time to assess correlation of CA 15–3 CSF concentration and cytology with disease status. Results At the time of initial testing, seven of the nine patients (78%) had positive cytology. Two samples (22%) had quantifiable CA 15–3, both of which were also positive by cytology. The positive concordance between all cytology and CA 15–3 measurements was 9% (2/22), while negative concordance was 100% (30/30). Sequential CA 15–3 and cytology measurements showed a decrease in CA 15–3 that paralleled changes observed with cytology. Conclusions In this cohort of patients, CA 15–3 CSF performance was neither superior nor complementary to cytology for the detection of LM, nor did the combination of CA 15–3 CSF and cytology improve performance over cytology alone. |
| Databáze: | OpenAIRE |
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