Menstrual disturbance and galactorrhea in people taking conventional antipsychotic medications
| Autor: | S. Geetanjali, Karthik Thangavelu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Galactorrhea Adolescent media_common.quotation_subject Pharmacotherapy Pregnancy Medicine Childbirth Endocrine system Humans Pharmacology (medical) Psychiatry Amenorrhea Menstrual cycle Menstrual Cycle media_common Pharmacology business.industry Sequela Middle Aged medicine.disease Psychiatry and Mental health Cross-Sectional Studies Female medicine.symptom business Antipsychotic Agents |
| Zdroj: | Experimental and clinical psychopharmacology. 14(4) |
| ISSN: | 1064-1297 |
| Popis: | Endocrine disturbances are emerging as major side effects of antipsychotic medications. Of particular note is the profile of menstrual disturbance and galactorrhea as a consequence of hyperprolactinemia (A. Weick & P. M. Haddad, 2003), a sequela of antidopaminergic action at the hypothalamopituitary axis. Research into the clinical aspects of this sensitive issue is sparse. The authors completed a cross-sectional descriptive study of 50 patients on conventional antipsychotic medications. The prevalence of menstrual disturbance was 54%, and the prevalence of amenorrhea was 12%. Symptoms of galactorrhea were present in 32% of patients. A history of pregnancy and childbirth was noted to be significantly associated with the development of galactorrhea (p = .01). The authors hypothesized that pregnancy and lactation might sensitize the hypothalamopituitary axis for further development of hyperprolactinemia due to medications. |
| Databáze: | OpenAIRE |
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