Serum Ubiquinone-10 in a Pediatric Population
| Autor: | Rafael Artuch, Montserrat Quintana, Rosa M. Puig, M. Antònia Vilaseca, Joan Moreno |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Ubiquinone Clinical Biochemistry Physiology Helsinki declaration Reference Values Humans Medicine Oxidative injury Child Chromatography High Pressure Liquid Free-radical theory of aging ATP synthase biology business.industry Biochemistry (medical) Infant Reference intervals Mitochondrial respiratory chain Child Preschool Reference values biology.protein Female business Pediatric population |
| Zdroj: | Clinical Chemistry. 44:2378-2379 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/44.11.2378 |
| Popis: | Ubiquinone-10 is a lipid implicated in several biological functions. In tissues, it has an important role in electron transport and ATP synthesis related to the mitochondrial respiratory chain. The reduced form of ubiquinone protects cells from peroxidative damage (1). In blood, ubiquinone-10 is transported by lipoproteins, is one of the antioxidants within LDL, and prevents free radical damage caused by neutrophils and oxidative injury by endothelial cells in ischemia-reperfusion (1). Adequate serum concentrations of ubiquinone seem necessary to prevent peroxidative damage. Various procedures to measure total ubiquinone-10 have been described, with HPLC with ultraviolet (UV) detection being the most common (2). Reference intervals for adults (3) and newborns (4) have been reported, but to our knowledge, no data are available for children. Our aim was to establish serum reference values for a pediatric population in our geographical area with our working conditions. Specimens were collected from apparently healthy children (by history and analytical data) before minor surgical intervention (n = 102; 38 females and 64 males; ages, 1 month–18 years), in accordance with the Helsinki Declaration of 1975, as revised in 1983. We collected 1.5 … |
| Databáze: | OpenAIRE |
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