Inflammation in Laparoendoscopic Single-Site Surgery Versus Laparoscopic Cholecystectomy
| Autor: | Fernando Athayde Veloso Madureira, Antonio Carlos Iglesias, José Eduardo Ferreira Manso, Delta Madureira Filho |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Umbilicus (mollusc) medicine.medical_treatment law.invention Young Adult Postoperative Complications Randomized controlled trial law medicine Humans Prospective Studies Laparoscopy Laparoscopic cholecystectomy Aged Inflammation medicine.diagnostic_test business.industry Mean age Middle Aged University hospital Surgery Cholecystectomy Laparoscopic Anesthesia Single site surgery Female Cholecystectomy business Brazil |
| Zdroj: | Surgical Innovation. 21:263-268 |
| ISSN: | 1553-3514 1553-3506 |
| DOI: | 10.1177/1553350613499454 |
| Popis: | Introduction. Laparoendoscopic single-site surgery (LESS) uses a multiple-entry portal in a single 3.0- to 4.0-cm incision in a natural scar, the umbilicus. The present study aimed to compare the inflammatory impact of classic video laparoscopic cholecystectomy (LC) versus LESS cholecystectomy. Methods. A prospective randomized controlled study was conducted from January to June 2011 at 2 university hospitals in Rio de Janeiro, Brazil. Fifty-seven patients (53 women, 4 men; mean age = 48.7 years) were randomly assigned to receive LC (n = 29) or LESS (n = 28) cholecystectomy. C-reactive protein (CRP) and interleukin 6 (IL-6) were measured from blood samples collected during induction of anesthesia and at 3 and 24 hours postoperatively. Results. Median IL-6 levels in the LESS and LC groups, respectively, were 2.96 and 4.5 pg/mL preoperatively, 11.6 and 28.05 pg/mL at 3 hours postoperatively ( P = .029), and 13.18 and 15.1 pg/mL at 24 hours postoperatively ( P = .52). Median CRP levels in the LESS and LC groups, respectively, were 0.33 and 0.44 mg/mL preoperatively, 0.40 and 0.45 mg/mL ( P = .73) at 3 hours postoperatively, and 1.7 and 1.82 mg/mL ( P = .84) at 24 hours postoperatively. We did not find a significant association between IL-6 (and CRP) and body mass index in the LESS group. Conclusions. LESS cholecystectomy requires a larger size incision than LC. We found a tendency of less postoperative pain following LESS cholecystectomy than LC. There was also a tendency toward lower early inflammatory impact following LESS cholecystectomy versus LC. |
| Databáze: | OpenAIRE |
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