Coeliac Disease in Elderly Patients: Value of Coeliac Lymphogram for Diagnosis
| Autor: | Luis Fernández-Salazar, Natalia López-Palacios, Judith Vidal, F Fernández-Bañares, Ana Pilar Lanzarote, Sergio Farrais, Cristina Serrano, Josefa Melero, Pablo Ruiz-Ramírez, Aureli Esquerda, Montserrat Planella, Marta Aguilar-Criado, Concepción Núñez, Santiago Vivas |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty TCRγδ+ Sensitivity and Specificity elderly Gastroenterology Article Coeliac disease Internal medicine medicine Humans CD3− TX341-641 Lymphocyte Count Intestinal Mucosa Geriatric Assessment Aged Retrospective Studies Nutrition and Dietetics Nutrition. Foods and food supply business.industry flow cytometry nutritional and metabolic diseases coeliac Middle Aged medicine.disease digestive system diseases Celiac Disease Intraepithelial lymphocyte Female business Cytometry Food Science |
| Zdroj: | Nutrients Volume 13 Issue 9 Nutrients, Vol 13, Iss 2984, p 2984 (2021) |
| ISSN: | 2072-6643 |
| Popis: | (1) Background: Although a meta-analysis reported that the sensitivity of CD3+ TCRγδ+ cells for coeliac disease diagnosis was > 93%, a recent study has suggested that sensitivity decreased to 65% in elderly patients. (2) Aim: To evaluate whether the sensitivity of intraepithelial lymphocyte cytometric patterns for coeliac disease diagnosis changes with advanced age. (3) Methods: We performed a multicentre study including 127 coeliac disease patients ≥ 50 years: 87 with baseline cytometry (45 aged 50–59 years 23 aged 60–69 years 19 aged ≥ 70 years), 16 also with a follow-up cytometry (on a gluten-free diet) and 40 with only follow-up cytometry. (4) Results: In Marsh 3 patients, a sensitivity of 94.7%, 88.9% and 86.7% was observed for each age group using a cut-off value of TCRγδ+ > 10% (p = 0.27) and a sensitivity of 84.2%, 83.4% and 53.3% for a cut-off value > 14% (p = 0.02 50–69 vs. ≥70 years), with difference between applying a cut-off of 10% or 14% (p = 0.008). The TCRγδ+ count in the ≥70 years group was lower than in the other groups (p = 0.014). (5) Conclusion: In coeliac patients ≥ 70 years, the TCRγδ+ count decreases and the cut-off point of > 10% is more accurate than > 14%. |
| Databáze: | OpenAIRE |
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