Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes
| Autor: | Irena Tsui, Patrícia Brasil, Stephanie L. Gaw, Maria Elizabeth Lopes Moreira, Karin Nielsen-Saines, Patrícia Carvalho de Sequeira, James D. Cherry, Ana Maria Bispo de Filippis, José Henrique Pilotto, Umme-Aiman Halai, Rita Maria Ribeiro Nogueira, Claudia Raja Gabaglia, Jose Paulo Pereira Junior, Andrea Zin, Kristina Adachi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Zika virus disease Abnormal Pregnancy Reproductive health and childbirth Antibodies Viral Severity of Illness Index Medical and Health Sciences Zika virus Dengue fever 0302 clinical medicine Pregnancy 2.1 Biological and endogenous factors Viral Prospective Studies 030212 general & internal medicine Pregnancy Complications Infectious Aetiology Articles and Commentaries Neurologic Examination Pediatric screening and diagnosis biology Zika Virus Infection Infectious Brain Viral Load Middle Aged Biological Sciences Detection Infectious Diseases RNA Viral Female Infection Live Birth Viral load Brazil Adult Microbiology (medical) medicine.medical_specialty Adolescent Neuroimaging macromolecular substances Nervous System Malformations Microbiology Antibodies Young Adult 03 medical and health sciences Zika Rare Diseases Clinical Research Internal medicine Severity of illness Genetics medicine Humans Conditions Affecting the Embryonic and Fetal Periods Fetal Death ZIKV business.industry Prevention congenital Zika Virus Odds ratio Dengue Virus Perinatal Period - Conditions Originating in Perinatal Period medicine.disease biology.organism_classification dengue 4.1 Discovery and preclinical testing of markers and technologies Pregnancy Complications Vector-Borne Diseases Good Health and Well Being 030104 developmental biology Immunology RNA Nervous System Diseases business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 65, iss 6 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies, or abnormal pregnancy/infant outcomes. Methods A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement, and duration of symptoms during ZIKV infection. ZIKV-RNA load was quantified by polymerase chain reaction (PCR) cycles in blood/ urine. Dengue immunoglobulin G (IgG) antibodies were measured at baseline. Adverse outcomes were defined as fetal loss or a live infant with grossly abnormal clinical or brain imaging findings. Regression models were used to study potential associations. Results 131 ZIKV-PCR positive pregnant women were scored for clinical disease severity, 6 (4.6%) had mild disease, 98 (74.8%) had moderate disease, and 27 (20.6%) severe manifestations of ZIKV infection. There were 58 (46.4%) abnormal outcomes with 9 fetal losses (7.2%) in 125 pregnancies. No associations were found between: disease severity and abnormal outcomes (P = .961; odds ratio [OR]: 1.00; 95% confidence interval [CI]: 0.796-1.270); disease severity and viral load (P = .994); viral load and adverse outcomes (P = .667; OR: 1.02; 95% CI: 0.922-1.135); or existence of prior dengue antibodies (88% subjects) with severity score, ZIKV-RNA load or adverse outcomes (P = .667; OR: 0.78; 95% CI: 0.255-2.397). Conclusions Congenital ZIKV syndrome does not appear to be associated with maternal disease severity, ZIKV-RNA load at time of infection or existence of prior dengue antibodies. |
| Databáze: | OpenAIRE |
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