Androgen Synthesis by Testicular Tissue from a Patient with Gonadal Insufficiency
| Autor: | Dorothy B. Villee, John D. Crawford, Margaret H. MacGillivray, Robert E. Scully, Bernard Kliman |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Adolescent medicine.drug_class Biopsy Endocrinology Diabetes and Metabolism Clinical Biochemistry Dehydroepiandrosterone Biology 17-alpha-Hydroxypregnenolone Tritium Biochemistry Endocrinology Internal medicine Testis Hydroxyprogesterones Pathology medicine Humans Testosterone Androstenedione Chromatography Sertoli Cells medicine.diagnostic_test Hypogonadism Biochemistry (medical) Leydig Cells Androgen Sertoli cell Spermatozoa Metabolism medicine.anatomical_structure Pregnenolone Androgens Spermatogenesis medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 25:506-513 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-25-4-506 |
| Popis: | Testicular tissue removed from a 15½-yr-old boy with delayed sexual maturation, despite normal levels of urinary gonadotropins for 2 yr, was shown to be capable of converting pregnenolone-7α-3H to androstenedione, testosterone, 17-hydroxyprogesterone and 16α-hydroxy pregnenolone. Microscopical examination of the tissue revealed almost complete lack of spermatogenesis and reduced numbers of spermatogonia. Leydig cells were present but reduced in number. Chromosomal studies of the testicular tissue showed a normal XY-46 pattern. This patient is considered unique in that, although his testes were capable of making androgens in vitro, and he was shown to be responsive to exogenous androgen, various clinical tests, including estimation of plasma testosterone, suggested insufficient androgen production in vivo. The testicular pathology found on microscopical examination is incompatible with the diagnosis of constitutional delayed adolescence. |
| Databáze: | OpenAIRE |
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