Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging
| Autor: | Stephanie E. Combs, Melanie Boxberg, Dieter Saur, Michael Quante, M. Feith, Wilko Weichert, Katja Steiger, Moritz Jesinghaus, Helmut Friess, Peter Klare, Dirk Wilhelm, Marianne Reiser, Frido Brühl, Björn Konukiewitz, Stefan Münch, Peer Kuhn, Roland M. Schmid, Alexander Scheiter |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Time Factors Esophageal Neoplasms Biopsy Clinical Decision-Making Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Tumor budding Cell Movement Predictive Value of Tests Internal medicine medicine Humans Stage (cooking) Aged Cell Proliferation Neoplasm Staging Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Patient Selection Hazard ratio Cell Differentiation Histology Retrospective cohort study Middle Aged Lymphatic Metastasis 030220 oncology & carcinogenesis Predictive value of tests Cohort Disease Progression Female 030211 gastroenterology & hepatology Surgery Esophageal Squamous Cell Carcinoma Neoplasm Grading Anatomy business |
| Zdroj: | American Journal of Surgical Pathology. 43:618-627 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000001230 |
| Popis: | Initial treatment planning in esophageal squamous cell carcinoma mainly relies on clinical staging. Recently, a highly prognostic grading system based on the cellular dissociation parameters Tumor Budding and Cell Nest Size has been proposed for resected esophageal squamous cell carcinoma. To probe for the transferability and relevance of this established novel grading system in the pretreatment setting, we evaluated Tumor Budding/Cell Nest Size in pretherapeutic biopsies of either primarily resected (cohort 1, n=80) or neoadjuvantly treated (cohort 2, n=75) esophageal squamous cell carcinoma. Grading data were correlated with clinicopathologic and survival parameters. High Tumor Budding Activity and small Cell Nest Size in pretherapeutic biopsies were strongly associated with shortened overall survival, disease-free survival, and disease-specific survival in both cohorts. A modified histopathologic grading system incorporating both factors termed "Cellular Dissociation Grade" showed excellent prognostic demarcation between well (G1), moderately (G2), and poorly differentiated (G3) carcinomas in both scenarios (overall survival: cohort 1: P |
| Databáze: | OpenAIRE |
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