MMP-2 and MMP-9 Polymorphisms and Preeclampsia Risk in Tunisian Arabs: A Case-Control Study
| Autor: | Touhami Mahjoub, Nozha Raguema, Ondrej Seda, Hedia Zitouni, Marwa Ben Ali Gannoun, Julie L. Lavoie, Meriem Mehdi |
|---|---|
| Přispěvatelé: | Université de Montréal. Faculté de médecine. École de kinésiologie et des sciences de l'activité physique |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Single-nucleotide polymorphism Article Preeclampsia preeclampsia 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Genotype Medicine Allele Genotyping Pregnancy 030219 obstetrics & reproductive medicine MMP-2 business.industry Case-control study General Medicine medicine.disease 3. Good health Endocrinology genotyping 030220 oncology & carcinogenesis business MMP-9 SNPs |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 12 Journal of Clinical Medicine, Vol 10, Iss 2647, p 2647 (2021) |
| ISSN: | 2077-0383 |
| Popis: | The abnormal production of matrix metalloproteinases (MMPs), especially MMP-9 and MMP-2, plays a pivotal role in hypertensive disorders of pregnancy, and as such, can influence the development of preeclampsia. These alterations may result from functional genetic polymorphisms in the promoter region of MMP-9 and MMP-2 genes, which modify MMP-9 and MMP-2 expression. We investigated the association of MMP-9 polymorphism rs3918242 (-1562 C> T) and MMP-2 polymorphism rs2285053 (-735 C> T) with the risk of preeclampsia. This case–control study was conducted on 345 women with preeclampsia and 281 age-matched women with normal pregnancies from Tunisian hospitals. Genomic DNA was extracted from whole blood collected at delivery. Genotypes for -1562 C> T and -735 C> T polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). An increased frequency of heterozygous MMP-9 -1562 C/T genotype carriers was observed in women with preeclampsia compared to healthy controls (p = 0.03). In contrast, the MMP-2 -735 C> T polymorphism was not significantly different regarding frequency distribution of the allele and genotype between healthy pregnant women and women with preeclampsia. Our study suggests that the MMP-9 -1562 C/T variant, associated with high MMP-9 production, could be a genetic risk factor for preeclampsia in Tunisian women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|