17-Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta-analysis
| Autor: | Dwight J. Rouse, Thomas J. Garite, B.W.J. Mol, C.A. Combs, S. N. Caritis, Elizabeth Thom, Kimberly Maurel, Arianne C. Lim, Ewoud Schuit, Alan T.N. Tita |
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| Přispěvatelé: | RS: GROW - School for Oncology and Reproduction, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
17-Hydroxyprogesterone caproate Review Placebo Article 03 medical and health sciences 0302 clinical medicine Pregnancy 17 alpha-Hydroxyprogesterone Caproate Journal Article medicine Triplet Pregnancy Hydroxyprogesterones Humans 030212 general & internal medicine triplet pregnancy 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology progestogens medicine.disease Pregnancy Triplet Confidence interval multiple gestation Treatment Outcome Premature birth Relative risk Gestation Premature Birth Female Progestins business Hydroxyprogesterone caproate preterm birth prevention medicine.drug |
| Zdroj: | Bjog-an International Journal of Obstetrics and Gynaecology, 123(5), 682-690. Wiley BJOG-An International Journal of Obstetrics and Gynaecology. Wiley-Blackwell |
| ISSN: | 1471-0528 1470-0328 |
| Popis: | BACKGROUND: Preterm birth complicates almost all triplet pregnancies and no preventive strategy has proven effective. OBJECTIVE: To determine, using individual patient data (IPD) meta-analysis, whether the outcome of triplet pregnancy is affected by prophylactic administration of 17-hydroxyprogesterone caproate (17OHPc). SEARCH STRATEGY: We searched literature databases, trial registries and references in published articles. SELECTION CRITERIA: Randomised controlled trials (RCTs) of progestogens versus control that included women with triplet pregnancies. DATA COLLECTION AND ANALYSIS: Investigators from identified RCTs collaborated on the protocol and contributed their IPD. The primary outcome was a composite measure of adverse perinatal outcome. The secondary outcome was the rate of birth before 32 weeks of gestation. Other pre-specified outcomes included randomisation-to-delivery interval and rates of birth at |
| Databáze: | OpenAIRE |
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