Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients
| Autor: | Heinz Burgmann, Ludwig Traby, Marietta Kollars, Paul A. Kyrle, Bernhard Rössler, Alexander Hermann, Thomas Staudinger, Matthias Karer, Elisabeth Lobmeyr, Sabine Eichinger, Manuel Kussmann, Peter Schellongowski, Hana Šinkovec |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Platelets Male 0301 basic medicine Coronavirus disease 2019 (COVID-19) Disease 030204 cardiovascular system & hematology Extracellular Traps Severity of Illness Index Flow cytometry Histones Extracellular Vesicles 03 medical and health sciences Histone H3 0302 clinical medicine Immune system medicine Humans Thrombus Pandemics Aged Thromboinflammation medicine.diagnostic_test SARS-CoV-2 business.industry COVID-19 Hematology Middle Aged medicine.disease Pathophysiology 030104 developmental biology Case-Control Studies Immunoassay Immunology Citrullination Female business Biomarkers |
| Zdroj: | Thrombosis and Haemostasis. 122:113-122 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/a-1522-4131 |
| Popis: | Objectives Pulmonary thrombus formation is a hallmark of coronavirus disease 2019 (COVID-19). A dysregulated immune response culminating in thromboinflammation has been described, but the pathomechanisms remain unclear. Methods We studied 41 adult COVID-19 patients with positive results on reverse-transcriptase polymerase-chain-reaction assays and 37 sex- and age-matched healthy controls. Number and surface characteristics of extracellular vesicles (EVs) and citrullinated histone H3 levels were determined in plasma upon inclusion by flow cytometry and immunoassay. Results In total, 20 patients had severe and 21 nonsevere disease. The number of EV (median [25th, 75th percentile]) was significantly higher in patients compared with controls (658.8 [353.2, 876.6] vs. 435.5 [332.5, 585.3], geometric mean ratio [95% confidence intervals]: 2.6 [1.9, 3.6]; p Conclusion EV and citrullinated histone H3 are associated with COVID-19 and could provide information regarding pathophysiology of the disease. |
| Databáze: | OpenAIRE |
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