Age increases anxiety and reactivity of the fear/anxiety circuit in Lewis rats
| Autor: | Jolanta Zagrodzka, Ksenia Z. Meyza, Paweł M. Boguszewski, Evgeni Nikolaev |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Aging Hippocampus Fear anxiety Anxiety Behavioral Neuroscience Internal medicine Neural Pathways medicine Lewis rats Animals Reactivity (psychology) Maze Learning Analysis of Variance Principal Component Analysis Stressor Brain Immobility Response Tonic Fear Rats Disease Models Animal Endocrinology Gene Expression Regulation Hypothalamus Ageing Rats Inbred Lew Exploratory Behavior medicine.symptom Psychology Neuroscience Proto-Oncogene Proteins c-fos |
| Zdroj: | Behavioural brain research. 225(1) |
| ISSN: | 1872-7549 |
| Popis: | A growing body of data indicates that changes in emotional behavior occur with age. Young Lewis rats are known to display hypofunction of the HPA axis. With age the reactivity of this axis is thought to increase with a concomitant rise in anxiety. In the current study, we investigate how and if the pattern of neuronal activation (measured as c-Fos protein expression) in Lewis rat brains changes with age and in response to novel environments differing in aversiveness. We found that distinct parts of the fear/anxiety circuit (i.e., the amygdalar complex, hippocampus and hypothalamus) undergo diverse age-related changes in response to behavioral challenges. While in the hypothalamus an increase in responsivity to mild stressors was observed with age, no such effect was present in the hippocampus. The amygdalar complex (especially the medial and cortical nuclei) on the other hand exhibited an age-dependent decrease in neuronal activation to mild stressors. This was accompanied by a marked increase in anxiety not correlated with a decline in locomotor activity. |
| Databáze: | OpenAIRE |
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