Tumor-derived exosomes: Potential biomarkers and therapeutic target in the treatment of colorectal cancer
Autor: | Roya Moallem, Ramin Mardani, Seyed Mahdi Hassanian, Sousan Mousavi, Mahsa Sadeghzade, Majid Khazaei, Gordon A. Ferns, Amir Avan |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Physiology Colorectal cancer Clinical Biochemistry Disease Exosomes 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems microRNA medicine Biomarkers Tumor Tumor Microenvironment Humans RNA Neoplasm Early Detection of Cancer Messenger RNA business.industry RNA Cancer Cell Biology DNA Neoplasm Tumor-Derived medicine.disease Microvesicles MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Disease Progression business Colorectal Neoplasms |
Zdroj: | Journal of cellular physiology. 234(8) |
ISSN: | 1097-4652 |
Popis: | Colorectal cancer (CRC) is the third most common cause of cancer-related death in men and women in many countries. Early detection of CRC helps to prevent the advanced stages of the disease, and may thereby improve the survival of these patients. A noninvasive test with high specificity and sensitivity is required for this. Exosomes are lipid bilayer membrane nanovesicles that are released into most body fluids and especially in the microenvironment of cancer. They carry various proteins, lipids, and nucleic materials such as DNA, RNA, messenger RNA (mRNA), and microRNA (miRNA), and may also alter the function of target cells. In this review, we aimed to describe the biogenesis, composition, function, and the role of tumor-derived exosomes in cancer progression. Moreover, their applications in tumor diagnosis and treatment are described, with a particular focus on CRC. |
Databáze: | OpenAIRE |
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