Crystallization of Monohydrate Citric Acid. 1. In Situ Monitoring through the Joint Use of Raman Spectroscopy and Image Analysis
| Autor: | Alain Rivoire, Jean-Marc Galvan, François Puel, Gilles Févotte, Alexandre Caillet |
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| Přispěvatelé: | Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), CPE Lyon, Domaine scientifique de La Doua |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
In situ
AGGLOMERATION Analytical chemistry Nucleation Infrared spectroscopy 02 engineering and technology 010402 general chemistry 01 natural sciences Isothermal process SUSPENSION law.invention INFRARED-SPECTROSCOPY symbols.namesake chemistry.chemical_compound law General Materials Science MEDIATED POLYMORPHIC TRANSFORMATION [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Crystallization PARTICLE-SIZE DISTRIBUTION CHORD LENGTH MEASUREMENTS General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences chemistry symbols Particle size 0210 nano-technology Raman spectroscopy Citric acid |
| Zdroj: | Crystal Growth & Design Crystal Growth & Design, American Chemical Society, 2007, 7 (10), pp.2080-2087. ⟨10.1021/cg060557b⟩ |
| ISSN: | 1528-7483 1528-7505 |
| DOI: | 10.1021/cg060557b⟩ |
| Popis: | International audience; Seeded batch crystallizations of monohydrate citric acid were performed under isothermal conditions (15 degrees C). Continuous monitoring of the overall solid concentration during the crystallization process was developed using in situ Raman spectroscopy. Quantitative estimation of the crystal size distribution (CSD) was made possible thanks to in situ image acquisition: off-line CSD measurements were further computed from the recorded pictures. The growth rate of monohydrate citric acid was estimated from solid concentration. Through in situ particle size visualization and quantitative analysis of the pictures, activated surface secondary nucleation was also shown to significantly impact the final CSD. It is underlined that, in addition to continuous Raman in situ spectroscopic concentration measurements, image acquisition yields highly valuable data on the dispersed phase. Advantages and drawbacks of the technique for the monitoring of solution crystallization are discussed. |
| Databáze: | OpenAIRE |
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