A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats

Autor: Jamal Amri, Mohammad Parastesh, Mehdi Salehi, Mehdi Sadegh, Mohammad Bayat, Mona Alaee, Hadi Karami, Ahmad Akbari, Seied Amirhossein Latifi
Rok vydání: 2020
Předmět:
Blood Glucose
Male
Niacinamide
0301 basic medicine
medicine.medical_specialty
Betatrophin
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Type 2 diabetes
Streptozocin
Diabetes Mellitus
Experimental
Random Allocation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Angiopoietin-Like Protein 8
Endurance training
Physical Conditioning
Animal
Internal medicine
Diabetes mellitus
medicine
Animals
Insulin
Rats
Wistar
Risk factor
Molecular Biology
Nicotinamide
business.industry
Body Weight
Resistance Training
General Medicine
Streptozotocin
medicine.disease
Lipids
Fibronectins
Rats
Endurance Training
Angiopoietin-like Proteins
030104 developmental biology
chemistry
Insulin Resistance
business
medicine.drug
Zdroj: Hormone Molecular Biology and Clinical Investigation. 41
ISSN: 1868-1891
1868-1883
Popis: Background Physical inactivity is the major risk factor for type 2 diabetes (T2D). The present study was conducted to investigate the effects of resistance training and endurance training on diabetic-related metabolic parameters in diabetic rats. Materials and methods Twenty-four male Wistar rats were randomly assigned to four groups of six rats each: control group (C), diabetic group (D), resistance training group (RES) and endurance training group (END). T2D was induced intraperitoneally using nicotinamide (120 mg/kg) and streptozotocin (STZ, 65 mg/kg). The training period was 70 days. The irisin, betatrophin, insulin, fasting blood glucose (FBG) and lipid profiles were measured in the serum of all rats. Results Diabetes significantly increased serum levels of FBG (p < 0.001), which were decreased significantly after the administration of training (p < 0.001). Training administration had a significant effect in normalizing serum lipid profiles (p < 0.001) and it was shown to increase the serum levels of irisin, betatrophin (p < 0.001) and insulin (END: p < 0.001 and resistance training: p < 0.05). It was also found that the endurance training was more effective in improving this parameters when compared with resistance training (p < 0.05). In addition, the irisin revealed a significant positive association with betatrophin (END: p < 0.01 and resistance training: p < 0.05) and insulin (END: p < 0.01 and RES: p < 0.05) values in diabetic groups. Conclusion This study demonstrated that endurance training was more effective in diabetic related metabolic derangement compared with resistance training. This effect is probably due to better regulation of irisin, betatrophin and insulin relative to resistance training.
Databáze: OpenAIRE
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