Melanocytes contribute to the vasculature of the choroid
| Autor: | Toshihiko Shiroishi, Koji Ohba, Kaoru Ichimura, Hirotoshi Shibuya, Shigeharu Wakana, Hiroaki Yamamoto, Hiroshi Tomita, Masaru Tamura, Kazuhisa Takeda, Shigeki Shibahara, Ryutaro Watanabe, Akiteru Maeno |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mutant Morphogenesis Neovascularization Physiologic Biology Melanocyte 03 medical and health sciences Mice 0302 clinical medicine biology.animal Genetics medicine Animals Inner ear Molecular Biology Hearing ability Microphthalmia-Associated Transcription Factor Choroid Neural crest Vertebrate General Medicine Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Melanocytes sense organs |
| Zdroj: | Genesgenetic systems. 93(2) |
| ISSN: | 1880-5779 |
| Popis: | Melanocytes develop from the vertebrate embryo-specific neural crest, migrate, and localize in various organs, including not only the skin but also several extracutaneous locations such as the heart, inner ear and choroid. Little is known about the functions of extracutaneous melanocytes except for cochlear melanocytes, which are essential for hearing ability. In this study, we focused on the structure of the choroid, in which melanocytes are abundant around the well-developed blood vascular system. By comparing structural differences in the choroid of wild-type and melanocyte-deficient Mitfmi-bw/Mitfmi-bw mutant mice, our observations suggest that choroidal melanocytes contribute to the morphogenesis and/or maintenance of the normal vasculature structure of that tissue. |
| Databáze: | OpenAIRE |
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