Alteration of Ventricular Fibrillation by Flecainide, Verapamil, and Sotalol
| Autor: | Luis Such, Francisco J. Chorro, Juan Sanchis, Joaquín Cánoves, Vicente López-Merino, Luis Mainar, Juan Guerrero |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Refractory Period Electrophysiological Heart disease Refractory period medicine.medical_treatment Antiarrhythmic agent Nerve conduction velocity Heart Conduction System Physiology (medical) Internal medicine medicine Animals Flecainide business.industry Sotalol Cardiac Pacing Artificial medicine.disease Electrophysiology Verapamil Ventricular Fibrillation Ventricular fibrillation Cardiology Rabbits Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background —The purpose of this study was to determine whether the myocardial electrophysiological properties are useful for predicting changes in the ventricular fibrillatory pattern. Methods and Results —Thirty-two Langendorff-perfused rabbit hearts were used to record ventricular fibrillatory activity with an epicardial multiple electrode. Under control conditions and after flecainide, verapamil, or d,l -sotalol, the dominant frequency (FrD), type of activation maps, conduction velocity, functional refractory period, and wavelength (WL) of excitation were determined during ventricular fibrillation (VF). Flecainide (1.9±0.3 versus 2.4±0.6 cm, P P P r =0.66, P r =0.33, P r =0.49, P Conclusions —The activation frequency is inversely related to WL during VF, although a closer relation is observed with the functional refractory period. Despite the diverging effects of verapamil versus flecainide and sotalol on the activation frequency, WL, and size of the reentrant circuits, all 3 drugs reduce activation pattern complexity during VF. |
| Databáze: | OpenAIRE |
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