Endothelial Contributions to Zebrafish Heart Regeneration
| Autor: | Cristina E. Fernandez, Melanie Bakovic, Ravi Karra |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system Cell type endothelium Endothelium medicine.medical_treatment Morphogenesis Review Revascularization 03 medical and health sciences vascular medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Zebrafish biology business.industry Regeneration (biology) cardiac regeneration Coronary vasculature biology.organism_classification 030104 developmental biology medicine.anatomical_structure lcsh:RC666-701 Signal transduction business Neuroscience |
| Zdroj: | Journal of Cardiovascular Development and Disease Journal of Cardiovascular Development and Disease, Vol 5, Iss 4, p 56 (2018) |
| ISSN: | 2308-3425 |
| Popis: | Studies over the past two decades have shown heart regeneration in zebrafish to be a dynamic process, choreographed by multiple cell types. In particular, recent work has identified revascularization of the wound to be a sentinel event during heart regeneration. The cardiac endothelium has emerged as a key orchestrator of heart regeneration, influencing cardiomyocyte hyperplasia and tissue morphogenesis. Here, we review how the coronary vasculature regenerates after injury, how signaling pathways link the cardiac endothelium to heart regeneration, and how understanding these signaling dynamics can lead to targeted therapies for heart regeneration. |
| Databáze: | OpenAIRE |
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