Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy
| Autor: | Kwang Ik Yang, Dongyeop Kim, Hyun Jin Jo, Seung Bong Hong, Jeong Sik Kim, Joo Yeon Song, Yoon Ha Hwang |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Long term treatment medicine.medical_treatment suicidality 03 medical and health sciences Epilepsy 0302 clinical medicine Quality of life Internal medicine medicine 030212 general & internal medicine Depression (differential diagnoses) business.industry Therapeutic effect vagus nerve stimulation Drug Resistant Epilepsy medicine.disease Mood Neurology quality of life depression epilepsy Original Article Neurology (clinical) business 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Journal of Clinical Neurology (Seoul, Korea) |
| ISSN: | 1738-6586 |
| Popis: | BACKGROUND AND PURPOSE This study aimed to determine the long-term effects of vagus nerve stimulation (VNS) treatment on suicidality, mood-related symptoms, and quality of life (QOL) in patients with drug-resistant epilepsy (DRE). We also investigated the relationships among these main effects, clinical characteristics, and VNS parameters. METHODS Among 35 epilepsy patients who underwent VNS implantation consecutively in our epilepsy center, 25 patients were recruited to this study for assessing the effects of VNS on suicidality, mood-related symptoms, and QOL. The differences in these variables between before and after VNS treatment were analyzed statistically using paired t-tests. Multiple linear regression analyses were also performed to determine how the patients' demographic and clinical characteristics influenced the variables that showed statistically significant changes after long-term VNS treatment. RESULTS After VNS, our patients showed significant improvements not only in the mean seizure frequency but also in suicidality, depression, and QOL. The reduction in depression was associated with the improvement in QOL and more-severe depression at baseline. The reduction in suicidality was associated with higher suicidality at baseline, smaller changes in depression, and less-severe depression at baseline. Improved QOL was associated with lower suicidality at baseline. CONCLUSIONS This study found that VNS decreased the mean seizure frequency in patients with DRE, and also improved their depression, suicidality, and QOL. These results provide further evidence for therapeutic effect of VNS on psychological comorbidities of patients with DRE. |
| Databáze: | OpenAIRE |
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