Ultrasonic nebulized in comparison with instilled surfactant treatment of preterm lambs
| Autor: | Alan H. Jobe, M D Henry, Jonathan M. Davis, Machiko Ikegami, Celso Moura Rebello, E G Langenback |
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| Rok vydání: | 1996 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pulmonary compliance Critical Care and Intensive Care Medicine Surfactant therapy Pulmonary surfactant Administration Inhalation Animals Humans Medicine Lung Lung Compliance Aerosols Respiratory Distress Syndrome Newborn Sheep Respiratory distress Inhalation business.industry Nebulizers and Vaporizers Respiratory disease Infant Newborn Pulmonary Surfactants medicine.disease Instillation Drug medicine.anatomical_structure Animals Newborn Anesthesia Respiratory Mechanics Breathing business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 154:366-375 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.154.2.8756808 |
| Popis: | To evaluate the efficiency and distribution of ultrasonic nebulized versus instilled surfactant in the treatment of surfactant deficiency at varying degrees of maturation, twin or triplet lamb fetuses were delivered at 125 to 137 d gestational age and received nebulized natural surfactant (Neb Only), instilled surfactant followed by a second instilled dose (Inst/Inst), instilled surfactant followed by nebulized surfactant (Inst/Neb), or no surfactant (Control). The lambs were ventilated for 6 h. Twenty-eight lambs were categorized into two groups (low compliance versus moderate compliance) based on initial physiologic lung characteristics. Efficiency of deposition of nebulized surfactant directly correlated with the compliances and ventilatory efficiency indices measured at 15 min of age. The low-compliance group (Low Comp) had significantly lower efficiency of surfactant deposition (7.6 +/- 1.6%) than did the moderate-compliance group (Mod Comp) (23.4 +/- 2.5%) (p < 0.01). Overall, instilled surfactant had a reasonably homogeneous distribution, whereas nebulized surfactant had a less homogeneous distribution, except for the Low Comp, Inst/Neb group, which had a distribution pattern similar to that for instilled surfactant. The potential for nebulized surfactant therapy for respiratory distress syndrome (RDS) may be limited by the nonhomogeneous nature of ventilation in the preterm lung. |
| Databáze: | OpenAIRE |
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