Inhibition of voltage-dependent potassium channels mediates cAMP-potentiated insulin secretion in rat pancreatic β cells
| Autor: | Xiangqin Zhong, Tao Bai, Jing Yang, Qing Guo, Yunfeng Liu, Yaqin Ding, Mengmeng Liu, Yangyan Guo, Yi Zhang, Zhihong Liu, Lele Ren, Yu Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Rats Sprague-Dawley Adenylyl cyclase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin-Secreting Cells Internal medicine Insulin Secretion Cyclic AMP Potassium Channel Blockers medicine Colforsin Animals Homeostasis Insulin Glucose homeostasis Forskolin Adenine Potassium channel blocker Potassium channel Rats 030104 developmental biology chemistry 030217 neurology & neurosurgery Intracellular Signal Transduction Research Paper medicine.drug |
| Zdroj: | Islets. 9:11-18 |
| ISSN: | 1938-2022 1938-2014 |
| Popis: | Insulin secretion is essential for maintenance of glucose homeostasis. An important intracellular signal regulating insulin secretion is cAMP. In this report, we showed that an increase of cAMP induced by adenylyl cyclase (AC) activator forskolin or by cAMP analog db-cAMP not only potentiated insulin secretion but also inhibited Kv channels, and these effects were reversed by AC inhibitor SQ22536. The cAMP-mediated Kv channel inhibition resulted in prolongation of action potential duration, which partly accounts for the elevation of intracellular Ca2+ induced by activation of cAMP signaling. Taken together, the results suggest that Kv channels are involved in cAMP-potentiated insulin secretion in pancreatic β cells. |
| Databáze: | OpenAIRE |
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