Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases
| Autor: | Aliza A. Le, Julie C. Lauterborn, Yousheng Jia, Weisheng Wang, Conor D. Cox, Christine M. Gall, Gary Lynch |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Sex Characteristics Neurology & Neurosurgery General Neuroscience Puberty Long-Term Potentiation Neurosciences Rodentia Hippocampus Basic Behavioral and Social Science Article Synapses Behavioral and Social Science Learning Animals Psychology Female Mental health Cognitive Sciences gamma-Aminobutyric Acid Spatial Memory |
| Zdroj: | Nature neuroscience, vol 25, iss 2 Nat Neurosci |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-021-01001-5 |
| Popis: | Multiple studies indicate that adult male rodents perform better than females on spatial problems and have a lower threshold for long-term potentiation (LTP) of hippocampal, CA3-to-CA1 synapses. We report here that in rodents, prepubescent females rapidly encode spatial information and express low threshold LTP, while age-matched males do not. The loss of low threshold LTP across female puberty was associated with three inter-related changes: increased densities of α5 subunit-containing GABA(A)Rs at inhibitory synapses, greater shunting of burst responses used to induce LTP, and a reduction of NMDAR-mediated synaptic responses. A negative allosteric modulator of α5-GABA(A)Rs increased burst responses to a greater degree in adult than in juvenile females and markedly enhanced both LTP and spatial memory in adults. The reasons for the gain of functions with male puberty do not involve these mechanisms. In all, puberty has opposite consequences for plasticity in the two sexes, albeit through different routes. |
| Databáze: | OpenAIRE |
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