The impact of hepatitis C viremia status on lung functions in chronic hepatitis c patients
| Autor: | Yusuf Yumer, Cenk Babayiğit, Selma İlkay Şahin, Yusuf Onlen, Tayibe Bal |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty 030231 tropical medicine Prevalence Viremia Hepacivirus Gastroenterology Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Chronic hepatitis Internal medicine medicine Humans Prospective Studies Lung viremia business.industry Articles lung function tests General Medicine Hepatitis C Hepatitis C Antibodies Hepatitis C Chronic Middle Aged Viral Load medicine.disease Chronic hepatitis C infection Respiratory Function Tests medicine.anatomical_structure Spirometry Chronic hepatitis C infection viremia lung function tests RNA Viral Female business Viral load |
| Zdroj: | African Health Sciences; Vol 19, No 2 (2019); 1988-1992 African Health Sciences |
| ISSN: | 1680-6905 |
| Popis: | Background: Previous trials have investigated the effect of hepatitis C on lung functions; however, the role of viral load levels is unclear. The aim of this study was to investigate the effect of HCV viremia status on lung functions. Methods: This study was in 60 patients with chronic hepatitis C (CHC). Patients were classified into three groups (non-viremic, low-viremic and high-viremic) based on serum HCV RNA levels. Spirometric parameters (FEV1, FVC, FEV1/FVC) and the proportion of patients with spirometric abnormalities were compared between three groups. Results: High-viremic and low-viremic patients showed a significantly higher prevalance of spirometric abnormality than observed in non-viremic patients (p=0.02). Moreover, there was a significant moderate correlation between viremia level and the percentage of spirometric abnormalities (Cramer’s U value=0.452, p=0.002). High-viremic patients were 14.2 times more likely to exhibiting pulmonary dysfunction than non-viremic patients. Additionally, spirometric parameters FEV1 and FVC were significantly reduced in high-viremic and low-viremic patients compared to those in non-viremic patients (p=0.013 and p |
| Databáze: | OpenAIRE |
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