Deletion mapping of the short arm of chromosome 8 in non-small cell lung carcinoma
| Autor: | Ken Nakagawa, Yusuke Nakamura, Reiko Futagami, Hiroyuki Ohata, Kazuya Higashino, Mitsuru Emi, Yoshiyuki Fujiwara, Eiju Tsuchiya |
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| Rok vydání: | 1993 |
| Předmět: |
Heterozygote
Cancer Research Lung Neoplasms Adenocarcinoma Biology Loss of heterozygosity Polymorphism (computer science) Carcinoma Non-Small-Cell Lung Genetics Carcinoma medicine Humans Deletion mapping Chromosome Mapping Chromosome Cancer Heterozygote advantage DNA Neoplasm medicine.disease Molecular biology Carcinoma Squamous Cell Restriction fragment length polymorphism Gene Deletion Polymorphism Restriction Fragment Length Chromosomes Human Pair 8 |
| Zdroj: | Genes, Chromosomes and Cancer. 7:85-88 |
| ISSN: | 1098-2264 1045-2257 |
| DOI: | 10.1002/gcc.2870070204 |
| Popis: | Frequent losses of heterozygosity observed at several chromosomal loci in primary lung cancers have indicated the existence of several tumor suppressor genes associated with this type of cancer. We have examined loss of heterozygosity on chromosomal arm 8p in 49 cases of non-small cell lung carcinoma, using 14 restriction fragment length polymorphism markers. Of 42 cases informative with at least one marker, 21 showed allelic loss, including 15 of 32 adenocarcinomas and 5 of 9 squamous cell carcinomas. The frequency of allelic loss on 8p was similar at all clinical stages. Deletion mapping defined a single common region of deletion in these tumors within an 8 cM interval at 8p21.3-p22 flanked by the loci defined by cMSR-32 and cC18-245. |
| Databáze: | OpenAIRE |
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