Antiprotozoal Sesquiterpene Pyridine Alkaloids from Maytenus ilicifolia
| Autor: | Regina Maria Barreto Cicarelli, Maysa Furlan, Vanderlan da Silva Bolzani, Marcia A. S. Graminha, Cláudio R. Nogueira, Isabel Martinez, Vania A. F. F. M. Santos, Gabriela Duó Passerini, Luis Octávio Regasini |
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| Rok vydání: | 2012 |
| Předmět: |
Pyridines
medicine.drug_class Stereochemistry Trypanosoma cruzi Antiprotozoal Agents Pharmaceutical Science Biology Sesquiterpene Plant Roots complex mixtures Analytical Chemistry Mice chemistry.chemical_compound Alkaloids parasitic diseases Drug Discovery medicine Animals Cytotoxicity Leishmania Pharmacology Molecular Structure Alkaloid Organic Chemistry Leishmania chagasi Maytenus biology.organism_classification In vitro Complementary and alternative medicine chemistry visual_art Macrophages Peritoneal Plant Bark visual_art.visual_art_medium Antiprotozoal Molecular Medicine Bark Sesquiterpenes Brazil |
| Zdroj: | Journal of Natural Products. 75:991-995 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np300077r |
| Popis: | As part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC(50) values of 1.4 and 41.9 μM, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC(50) of 1.8 mM). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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