Natural products and the aging process

Autor: Volkan Ergin, Elif Burcu Bali, Çimen Karasu, Reza Ebrahimi Hariry
Rok vydání: 2013
Předmět:
Zdroj: Hormone molecular biology and clinical investigation. 16(2)
ISSN: 1868-1891
Popis: Literature surveys show that the most of the research that have been conducted on the effect of herbal remedies on many tissue pathologies, including metabolic disturbances, cardiovascular decline, neurodegeneration, cataract, diabetic retinopathy and skin inflammation, all lead to an accelerated aging process. The increased car-bonylation of proteins (carbonyl stress) disturbing their function has been indicated as an underlying mechanism of cellular senescence and age-related diseases. Because it is also linked to the carbonyl stress, aging chronic disease and inflammation plays an important role in understanding the clinical implications of cellular stress response and relevant markers. Greater knowledge of the molecular and cellular mechanisms involved in several pathologies associated with aging would provide a better understanding to help us to develop suitable strategies, use specific targets to mitigate the effect of human aging, prevent particularly chronic degenerative diseases and improve quality of life. However, research is lacking on the herbal compounds affecting cellular aging signaling as well as studies regarding the action mechanism(s) of natural products in prevention of the age-related disease. This review provides leads for identifying new medici-nal agents or potential phytochemical drugs from plant sources for the prevention or delaying cellular aging pro-cesses and the treatment of some disorders related with accelerated body aging. Keywords: age-related diseases; body agin g; carbon ylstress; cellular stress; herbal phenolics; herbal eme-rdies; nutraceuticals; phytochemicals; protein oxidation; senescense.
Databáze: OpenAIRE
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