The Inflammatory and Hemostatic Cardiovascular Risk Markers During Acute Hyperglycemic Crisis in Type 1 and Type 2 Diabetes
| Autor: | Tanja Milicic, Maja Đorđevic, Sanja Stankovic, Aleksandra Jotic, Jelena Bogdanovic, Veljko Jeremic, Dragana Popovic, Katarina Lalic, Nebojsa Lalic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
inflamatorni markeri
medicine.medical_specialty endocrine system diseases Homocysteine Diabetic ketoacidosis medicine.medical_treatment 030209 endocrinology & metabolism Context (language use) Type 2 diabetes 030204 cardiovascular system & hematology Group A lcsh:Biochemistry hemotatski markeri 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine haemostatic markers lcsh:QD415-436 Interleukin 6 Original Paper biology business.industry Insulin nutritional and metabolic diseases cardiovascular risk markers medicine.disease inflammatory markers 3. Good health Endocrinology chemistry akutna hiperglikemijska kriza biology.protein Hyperosmolar hyperglycemic state acute hyperglycemic crisis business |
| Zdroj: | Journal of Medical Biochemistry Journal of Medical Biochemistry, Vol 38, Iss 2, Pp 126-133 (2019) |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS).In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA.Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p0.001; B: p0.001, C: p0.05; D: p0.001 mg/L), (A: p0.001 B: p0.001, C: p0.001, D: p0.01 pg/mL), (A: p0.001, B: p0.001; C: p0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p0.001, p0.01), IL-6 lower (p0.05, p0.001), while homocysteine levels turned out to be similar to controls.AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP.Analizirali smo kardiovaskularne inflamatorne (C-reaktivni protein (CRP), interleukin 6 (IL-6)) i (homocistein) hemotatske markere rizika u negojaznih i gojaznih pacijenata pri prijemu i razrešenju akutne hiperglikemijske krize (AHK), uključujući dijabetesnu ketoacidozu (DKA) i hiperosmolarno hiperglikemijsko stanje (HHS).U tom kontekstu uključili smo grupu A: N = 20 gojaznih, B: N = 20 negojaznih bolesnika sa DKA; C: N = 10 gojaznih, D: N = 10 negojaznih bolesnika sa HHS; E: N = 15 gojaznih, F: N = 15 negojaznih kontrola. Nivo CRP IL-6 i homocistein određeni su ELISA metodom.Naši rezultati su pokazali niže nivoe CRP IL-6 i homocisteina nakon rešavanja AHK u poređenju sa prijemom u svim grupama: (A: p0,001; B: p0,001, C: p0,05; D: p0,001 mg/L), (A: p0,001 B: p0,001; C: p0,05, D: p=0,001 mmol/L), (A: p0,00l, B: p0,001, C: p0,001, D: p0,01 pg/mL) nakon rešavanja AHK. Međutim, nivo CRP je ostao viši (p0,001, p0,01), IL-6 niži (p0,05, p0,001), dok je nivo homocisteina sličan u poređenju sa kontrolama.AHK su povezane sa povišenim nivoom inflamatornih i hemostatičnih kardiovaskularnih markera rizika. Takođe, terapija insulinom u AHK ima značajno povoljniji efekat na nivo IL-6 i homocisteina, nego na nivo CRP. |
| Databáze: | OpenAIRE |
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