Efficacy of Trypsin in Treating Coral Snake Envenomation in the Porcine Model
| Autor: | Kvin Lertpiriyapong, Dorcas O'Rourke, Jennifer L. Parker-Cote, Kori L. Brewer, Susan N. Miller, Sean P. Bush, William J. Meggs, Mohan Punja |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Respiratory rate Swine Health Toxicology and Mutagenesis medicine.medical_treatment Antivenom Snake Bites Toxicology Random Allocation Animals Medicine Trypsin Elapidae Envenomation Saline Coral snake Elapid Venoms biology business.industry Proteolytic enzymes biology.organism_classification Toxicology Investigation Surgery Disease Models Animal Anesthesia Toxicity Female business medicine.drug |
| Zdroj: | Journal of Medical Toxicology. 11:430-432 |
| ISSN: | 1937-6995 1556-9039 |
| Popis: | Antivenom is the definitive treatment for venomous snakebites. Alternative treatments warrant investigation because antivenom is sometimes unavailable, expensive, and can have deleterious side effects. This study assesses the efficacy of trypsin to treat coral snake envenomation in an in vivo porcine model. A randomized, blinded study was conducted. Subjects were 13 pigs injected subcutaneously with 1 mL of eastern coral snake venom (10 mg/mL) in the right distal hind limb. After 1 min, subjects were randomized to have the envenomation site injected with either 1 mL of saline or 1 mL of trypsin (100 mg/mL) by a blinded investigator. Clinical endpoint was survival for 72 h or respiratory depression defined as respiratory rate |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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