Functional connectivity: A source of variance in the association between cardiorespiratory fitness and cognition?
| Autor: | Emily L. Klamm, Liang Hu, Thomas R. Wójcicki, Michelle W. Voss, Heloisa Alves, Laura Chaddock, Ruchika Shaurya Prakash, Amanda N. Szabo, Edward McAuley, Kirk I. Erickson, Edward Malkowski, Siobhan M. White, Jennifer S. Kim, Arthur F. Kramer, Katherine S. Morris |
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| Rok vydání: | 2010 |
| Předmět: |
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Heart Diseases Cognitive Neuroscience Respiratory Tract Diseases Physical fitness Experimental and Cognitive Psychology Context (language use) Neuropsychological Tests Gyrus Cinguli Severity of Illness Index Article Developmental psychology Behavioral Neuroscience Surveys and Questionnaires medicine Humans Dementia Aerobic exercise Effects of sleep deprivation on cognitive performance Default mode network Aged Depressive Disorder Major Memory Disorders business.industry Cognition Cardiorespiratory fitness medicine.disease Magnetic Resonance Imaging Space Perception Female Nerve Net Cognition Disorders business Psychology human activities Cognitive psychology |
| Zdroj: | Neuropsychologia. 48:1394-1406 |
| ISSN: | 0028-3932 |
| DOI: | 10.1016/j.neuropsychologia.2010.01.005 |
| Popis: | Over the next twenty years the number of Americans diagnosed with dementia is expected to more than double (CDC 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer’s disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional connectivity as a function of aerobic fitness level. Finally, we examine the hypothesis that functional connectivity in the DMN is one source of variance in the relationship between aerobic fitness and cognition. Results demonstrate instances of both specific and global DMN connectivity mediating the relationship between fitness and cognition. We provide the first evidence for functional connectivity as a source of variance in the association between aerobic fitness and cognition, and discuss results in the context of neurobiological theories of cognitive aging and disease. |
| Databáze: | OpenAIRE |
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