Stromal micropapillary pattern predominant lung adenocarcinoma - a report of two cases
| Autor: | Yuji Sakuma, Miki Ohe, Yoichi Kameda, Haruhiko Nakayama, Tetsukan Woo, Kimitoshi Nawa, Takeshi Isobe, Kouzo Yamada, Sachie Osanai, Chikako Hasegawa, Kota Washimi, Tomoyuki Yokose, Rurika Hamanaka |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
lung adenocarcinoma micropapillary subtype stromal micropapillary pattern aerogeneous micropapillary pattern Pathology medicine.medical_specialty Stromal cell Histology Lung Neoplasms CD34 Case Report Biology Metastasis Pathology and Forensic Medicine Cytokeratin Stroma medicine lcsh:Pathology Humans Neoplasm Staging General Medicine Genes erbB-1 Middle Aged medicine.disease Immunohistochemistry Adenocarcinoma Papillary Lymphatic system Lymphatic Metastasis Mutation Adenocarcinoma lcsh:RB1-214 |
| Zdroj: | Diagnostic Pathology Diagnostic Pathology, Vol 6, Iss 1, p 92 (2011) |
| ISSN: | 1746-1596 |
| Popis: | Generally, adenocarcinomas with micropapillary pattern, featuring small papillary tufts lacking a central fibrovascular core, are thought to have poor prognosis. This pattern has been described in various organs. However, tumor cells with micropapillary pattern of lung adenocarcinoma are more often seen to float within alveolar spaces (aerogenous micropapillary pattern, AMP) than in fibrotic stroma like other organs (stromal micropapillary pattern, SMP) and SMP predominant lung adenocarcinoma (SMPPLA) has not been well described yet. We presented two cases of SMPPLA which were found in the last four years. Both the cases showed more than 50% of SMP in the tumor area. The majority of the stromal micropapillary clusters expressed MUC1 and epithelial membrane antigen along the outer surface of cell membrane. On the other hand, connective tissues surrounding stromal micropapillary clusters showed no reactivity for epithelial markers (thyroid transcription factor-1 and cytokeratin) or endothelial marker (D2-40 and CD34). It means clusters of SMP do not exist within air space or lymphatic or vessel lumens. The tumors with SMP often presented lymphatic permeation and vessel invasion, and intriguingly, one of the two cases showed metastasis to the mediastinal lymph node. Additionally, both the cases showed EGFR point mutations of exon 21. These results suggest that SMPPLA might be associated with poor prognosis and effective for EGFR tyrosine kinase inhibitors. |
| Databáze: | OpenAIRE |
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