The Leishmania donovani species complex: A new insight into taxonomy☆
| Autor: | Cristina Ballart, Fouad El Baidouri, Anna Fernández-Arévalo, Montserrat Gállego, Patrick Lami, Silvia Tebar, Francine Pratlong, Laurence Lachaud, Alba Abras, Christophe Ravel, Carme Muñoz |
|---|---|
| Přispěvatelé: | Universitat de Barcelona (UB), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), University of Hawai‘i [Mānoa] (UHM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Universitat de Girona (UdG) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MALDI-TOF Genotype 030231 tropical medicine Leishmania donovani complex MESH: Dogs MESH: Genotype MESH: Phlebotomus 03 medical and health sciences 0302 clinical medicine Dogs parasitic diseases medicine Animals Humans Sequencing MESH: Animals [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology Genetic variability MESH: Genetic Variation Allele Leishmania infantum Alleles Taxonomy Genetics MESH: Humans MESH: Leishmania donovani biology MESH: Alleles Genetic Variation biology.organism_classification medicine.disease MESH: Leishmania infantum Sandfly 030104 developmental biology Infectious Diseases Visceral leishmaniasis MESH: Leishmaniasis Visceral Phlebotomus Leishmaniasis Visceral Parasitology Taxonomy (biology) MLEE Leishmania donovani |
| Zdroj: | International Journal for Parasitology International Journal for Parasitology, Elsevier, 2020, 50 (13), pp.1079-1088. ⟨10.1016/j.ijpara.2020.06.013⟩ INTERNATIONAL JOURNAL FOR PARASITOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/j.ijpara.2020.06.013⟩ |
| Popis: | Among the 20 or so Leishmania spp. described as pathogenic for humans, those of the Leishmania donovani complex are the exclusive causative agents of systemic and fatal visceral leishmaniasis. Although well studied, the complex is taxonomically controversial, which hampers clinical and epidemiological research. In this work, we analysed 56 Leishmania strains previously identified as L. donovani, Leishmania archibaldi or Leishmania infantum, isolated from humans, dogs and sandfly vectors throughout their distribution area. The strains were submitted to biochemical and genetic analyses and the resulting data were compared for congruence. Our results show: i) a partial concordance between biochemical and genetic-based data, ii) very limited genetic variability within the L. donovani complex, iii) footprints of frequent genetic exchange along an east-west gradient, marked by a widespread diffusion of alleles across the geographical range, and iv) a large-scale geographical spreading of a few genotypes. From a taxonomic point of view, considering the absence of relevant terminology in existing classes, the L. dono-vani complex could be treated as a single entity. (C) 2020 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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