Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
| Autor: | Alberto Granato, Adalberto Merighi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Down syndrome Apical dendrite Neocortex Biology Article 03 medical and health sciences Cellular and Molecular Neuroscience Basal (phylogenetics) Fetal alcohol Dendritic spike 0302 clinical medicine Intellectual Disability Intellectual disability medicine Humans Pyramidal Cells Cell Biology General Medicine Dendrites Cerebral cortex medicine.disease 030104 developmental biology medicine.anatomical_structure Calcium Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cellular and Molecular Neurobiology |
| Popis: | Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction. |
| Databáze: | OpenAIRE |
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