| Autor: |
Daniel A Sweeney, Bonifride Tuyishimire, Neera Ahuja, John H Beigel, Tatiana Beresnev, Valeria D Cantos, Jose G Castro, Stuart H Cohen, Kaitlyn Cross, Lori E Dodd, Nathan Erdmann, Monica Fung, Varduhi Ghazaryan, Sarah L George, Kevin A Grimes, Noreen A Hynes, Kathleen G Julian, Sheetal Kandiah, Hannah Jang Kim, Corri B Levine, David A Lindholm, David C Lye, Ryan C Maves, Myoung-don Oh, Catharine Paules, Rekha R Rapaka, Willam R Short, Kay M Tomashek, Cameron R Wolfe, Andre C Kalil |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Open forum infectious diseases, vol 10, iss 5 |
| ISSN: |
2328-8957 |
| Popis: |
We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling for baseline and postrandomization patient characteristics. This finding provides a novel mechanism of benefit for baricitinib and supports the safety profile of this immunomodulator for the treatment of coronavirus disease 2019. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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