The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus
Autor: | Shingo Yamada, Kazuhiko Kotani, Hirokazu Takahashi, Yoshitaka Iwazu, Toshiyuki Yamada |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
endocrine system diseases 030204 cardiovascular system & hematology Gastroenterology lcsh:Chemistry 0302 clinical medicine Lp(a) Interquartile range oxidative stress Endothelial dysfunction Child lcsh:QH301-705.5 Spectroscopy biology General Medicine Lipoprotein(a) Middle Aged Computer Science Applications reactive hyperemia medicine.anatomical_structure Female Disease Susceptibility Oxidation-Reduction Adult medicine.medical_specialty Endothelium Adolescent endothelium Lipoproteins 030209 endocrinology & metabolism Catalysis Article Inorganic Chemistry 03 medical and health sciences Young Adult Internal medicine medicine Humans Physical and Theoretical Chemistry Molecular Biology Reactive hyperemia business.industry Organic Chemistry Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease Diabetes Mellitus Type 2 lcsh:Biology (General) lcsh:QD1-999 Endo-PAT biology.protein Hemoglobin Endothelium Vascular atherosclerosis business Biomarkers Lipoprotein |
Zdroj: | International Journal of Molecular Sciences Volume 20 Issue 19 International Journal of Molecular Sciences, Vol 20, Iss 19, p 4909 (2019) |
ISSN: | 1422-0067 |
DOI: | 10.3390/ijms20194909 |
Popis: | The ratio of oxidized lipoprotein(a) to native lipoprotein(a) (oxLp(a)/Lp(a)) may be a reasonable index for assessing endothelial dysfunction in type 2 diabetes mellitus (T2DM). The present study investigated whether the oxLp(a)/Lp(a) level is correlated with the endothelial function using the Endo-PATTM, a newly developed device, in patients with T2DM. A total of 63 patients with T2DM (mean age: 59 years old) were enrolled in the study. The patients&rsquo serum Lp(a) and oxLp(a) levels were measured using an enzyme-linked immunosorbent assay. The reactive hyperemia index (RHI) level was measured using an Endo-PATTM 2000. A correlation analysis between the measured variables was conducted. Among the patients, the mean hemoglobin A1c was 7.8%. The median level of oxLp(a)/Lp(a) was 0.28 (interquartile range: 0.07&ndash 0.54), and the mean RHI was 1.8 (standard deviation: 0.4). In a multiple linear regression analysis, the oxLp(a)/Lp(a) level was an independent, significant, and inverse variable for the RHI level (&beta = &minus 0.26, p < 0.05), along with male gender. A high oxLp(a)/Lp(a) level may reflect endothelial dysfunction, as assessed by the Endo-PATTM, in patients with T2DM. Further studies are warranted to confirm the observed findings. |
Databáze: | OpenAIRE |
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