The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus

Autor: Shingo Yamada, Kazuhiko Kotani, Hirokazu Takahashi, Yoshitaka Iwazu, Toshiyuki Yamada
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
endocrine system diseases
030204 cardiovascular system & hematology
Gastroenterology
lcsh:Chemistry
0302 clinical medicine
Lp(a)
Interquartile range
oxidative stress
Endothelial dysfunction
Child
lcsh:QH301-705.5
Spectroscopy
biology
General Medicine
Lipoprotein(a)
Middle Aged
Computer Science Applications
reactive hyperemia
medicine.anatomical_structure
Female
Disease Susceptibility
Oxidation-Reduction
Adult
medicine.medical_specialty
Endothelium
Adolescent
endothelium
Lipoproteins
030209 endocrinology & metabolism
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Young Adult
Internal medicine
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
Reactive hyperemia
business.industry
Organic Chemistry
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
medicine.disease
Diabetes Mellitus
Type 2
lcsh:Biology (General)
lcsh:QD1-999
Endo-PAT
biology.protein
Hemoglobin
Endothelium
Vascular
atherosclerosis
business
Biomarkers
Lipoprotein
Zdroj: International Journal of Molecular Sciences
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4909 (2019)
ISSN: 1422-0067
DOI: 10.3390/ijms20194909
Popis: The ratio of oxidized lipoprotein(a) to native lipoprotein(a) (oxLp(a)/Lp(a)) may be a reasonable index for assessing endothelial dysfunction in type 2 diabetes mellitus (T2DM). The present study investigated whether the oxLp(a)/Lp(a) level is correlated with the endothelial function using the Endo-PATTM, a newly developed device, in patients with T2DM. A total of 63 patients with T2DM (mean age: 59 years old) were enrolled in the study. The patients&rsquo
serum Lp(a) and oxLp(a) levels were measured using an enzyme-linked immunosorbent assay. The reactive hyperemia index (RHI) level was measured using an Endo-PATTM 2000. A correlation analysis between the measured variables was conducted. Among the patients, the mean hemoglobin A1c was 7.8%. The median level of oxLp(a)/Lp(a) was 0.28 (interquartile range: 0.07&ndash
0.54), and the mean RHI was 1.8 (standard deviation: 0.4). In a multiple linear regression analysis, the oxLp(a)/Lp(a) level was an independent, significant, and inverse variable for the RHI level (&beta
= &minus
0.26, p <
0.05), along with male gender. A high oxLp(a)/Lp(a) level may reflect endothelial dysfunction, as assessed by the Endo-PATTM, in patients with T2DM. Further studies are warranted to confirm the observed findings.
Databáze: OpenAIRE
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