Pituitary volume in patients with bipolar disorder and their first-degree relatives
| Autor: | Sophia Frangou, Stephen J. Wood, Valentina Lorenzetti, Matthew J. Kempton, Michio Suzuki, Jigar Jogia, Bridget Soulsby, Dennis Velakoulis, Christos Pantelis, Mark Walterfang, Tsutomu Takahashi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pituitary gland medicine.medical_specialty Bipolar Disorder Gastroenterology Reference Values Internal medicine Genetic predisposition medicine Image Processing Computer-Assisted Humans Genetic Predisposition to Disease Bipolar disorder First-degree relatives Depression (differential diagnoses) Depressive Disorder Major Brain Organ Size Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Endocrinology Schizophrenia Pituitary Gland Major depressive disorder Female Psychology Hypothalamic–pituitary–adrenal axis |
| Zdroj: | Journal of affective disorders. 124(3) |
| ISSN: | 1573-2517 |
| Popis: | Background: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been reported in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have yielded inconsistent findings. In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown. Method: We used MRI to investigate the pituitary volume in 29 remitted patients with BD, 49 of their first-degree relatives (of whom 15 had a diagnosis of Major Depressive Disorder), and 52 age- and gender-matched healthy controls. Results: BD patients had a significantly larger pituitary volume compared with their relatives and healthy controls. Pituitary volume did not differ between controls and healthy relatives or relatives diagnosed with major depression. Limitations: Direct measures of HPA function (i.e., hormonal levels) were not available. Conclusions: These findings suggest that enlarged pituitary volume is associated with disease expression but not genetic susceptibility to BD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect